Validating skin efficacy and safety through mechanistic research and layered evidence.

Starting with skin biology and active-ingredient research, we combine cellular studies, in vitro and 3D skin models, efficacy and safety evaluation, well-designed human studies, and clinical research at tertiary Grade A hospitals to build an evidence-led path from discovery to application.

SCIENTIFIC PUBLICATIONS653SCI and leading Chinese journal publicationsExplore scientific publications

PATENT KNOWLEDGE BASE407valid patentsExplore the patent knowledge base

INGREDIENT KNOWLEDGE BASE29approved new cosmetic ingredientsExplore the ingredient knowledge base

STANDARD DEVELOPMENT10national standardsView the R&D and standards pathway

GROUP STANDARDS78group standards

RESEARCH & INNOVATION

Research capabilities, a connected R&D network and innovation outcomes

01
SKIN RESEARCH & VALIDATION
Skin Research & Validation
Research questions, proprietary and collaborative models, multidimensional efficacy and safety evaluation, and representative studies.
02
GLOBAL RESEARCH
Global R&D Network
Research institutions, team responsibilities and cross-regional collaboration across our R&D network.
03
BOTANICAL SCIENCE
Distinctive Botanical Science
From botanical traceability and active screening to extraction, quality control and innovative ingredient development.
04
SCIENTIFIC PUBLICATIONS
Scientific Publications
Search titles, authors and research themes, and review abstracts, publication details and original sources.
05
PATENTS & TECHNOLOGY
Patents & Technology
Explore published patent information, the problems addressed, proposed innovations and their boundaries of application.

EVIDENCE CHAIN · END-TO-END R&D

A reviewable path from research question to demonstrated human efficacy.

01Define research questions from clinical practice and real user needs
02Discover and standardize distinctive Yunnan botanical resources
03Screen active ingredients and study their mechanisms of action
04Develop raw materials, formulations and delivery systems
05Evaluate with in vitro and 3D skin models across multiple dimensions
06Validate efficacy in human and clinical studies
07Translate research through intelligent manufacturing and quality control

RESEARCH INSTITUTIONS & PLATFORMS

A multidisciplinary R&D network across regions.

R&D hubs in Kunming, Shanghai, Paris and Tokyo focus on distinctive botanicals, skin biology, formulation, evaluation and international collaboration, supporting the full journey from fundamental research to product translation.

01 · KUNMING

Yunnan Distinctive Botanical Extraction Laboratory

Fundamental botanical research, active screening, green extraction, quality standards, new ingredient development and industrial translation.

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02 · SHANGHAI

Botanee Research Institute

Connecting fundamental skin research, ingredients, formulation, efficacy evaluation, clinical validation and pilot-scale registration.

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03 · PARIS

France Research Center

Collaborating with the Saint-Louis Hospital skin research center on skin biology, non-animal methods and 3D models.

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04 · TOKYO

Japan Innovation R&D Center

Researching complexion products, sun protection and advanced formulation for Asian skin characteristics.

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ADVANCED EVALUATION MODELS

Extending research with models that more closely reflect living systems.

We continue to investigate pluripotent stem-cell differentiation, organoid construction and transgenic zebrafish platforms for multi-organ toxicology and efficacy simulation, including dose-response relationships across models.